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Lipid Replacement Therapy®

What is Lipid Replacement Therapy?

All cells have a protective “shell” called a membrane that prevents damage to the cell. It is by nature porous, allowing nutrients to move into cells and the removal of waste without disrupting normal cell functions. Cell membranes are made of carbohydrates (sugar-glyco), phospholipids, and protein.

Lipid means fat (oils). Lipid Replacement Therapy® (LRT®) is the natural replacement of damaged lipids with precise supplements protected from oxidative damage. These are not the usual fats found in fish, butter, olive and other oils but are a unique combination of glycophospholipids clinically proven to repair the lipid portion of cell membranes and mitochondria.

The premise of LRT® is based on what is referred to as “free radical damage”. Free radical damage is the scientific explanation of how oxygen and other molecules damage fatty portions of the cell membrane leading to chronic degenerative disease. The assault of cell membranes comes from chronic infections (bacteria, viruses, yeast), nutritional deficiencies, environmental toxins, hormone imbalances and genetic dysfunctions.

If this cell membrane is not protected it results in Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) damage. The generation of ROS/RNS is meant to be neutralized by antioxidants found in food such as vitamins, minerals and antioxidant enzymes (ex. vitamins C, E, selenium, zinc, superoxide dismutase and catalase). They must be obtained from food or in supplement form.

Without an abundance of these nutrients or an inability to generate enough of them as in aging or disease, the body suffers from DNA mutations, further lipid oxidation, faulty cell metabolism and finally cell death. The underlying defective conditions often lead to cancer, metabolic diseases and chronic illness.

Mitochondria help maintain proper storage of calcium, form important blood components, aid in the detoxification of ammonia, form hormones like testosterone and estrogen, generate heat, and regulate membrane potential, cell proliferation and metabolism.

Most important, mitochondria are the cell’s “factory” responsible for ATP production. Low ATP production = fatigue. Fatigue is the most common reason for doctor visits and the most prevalent symptom in the majority of disease.

Mitochondrial damage occurs from stress, environmental toxins, pharmaceutical drugs, chronic infections and poor nutrition. This combination is predominant in 21st century living. Clinical studies confirm LRT® restorative properties in mitochondrial function in Chronic Fatigue Syndrome, fibromyalgia, cancer, Lyme’s disease, Autistic Spectrum Disorders and many other chronic diseases. As we age, our ability to repair damaged tissue becomes more difficult, in part from exposure to pesticides, herbicides and industrial solvents, pharmaceutical drugs, chronic stress and the depletion of nutrients from poor soil conditions and over processing of food. Added to that, most people do not digest their food well and are in great need of digestive enzymes.

What are the Clinical Uses of LRT®?

Fatigue –
The most common medical complaint associated with the majority of disease

Anti-Aging –
Restores mitochondrial function and prevents mutations

Cardiovascular Disease –
Reverses damage to heart tissue and blood vessels restoring healthy cardiovascular functioning

Chronic infections –
Reverses damage to mitochondrial, nuclear and other membranes

Diabetes –
Reduces cell membrane death and damage

Environmental toxins –
Reduces drug and radiation damage to tissues and cell membranes

Lipid Metabolic Diseases –
Restores healthy lipid functions in diabetes Type 2 and Metabolic Syndrome

Neurodegenerative disease –
Reduces neuron cell and mitochondrial death and cell membrane damage

Sensory diseases –
Reduces damage and restores healthy functions as in neuropathies

Tissue repair –
Increases healing and from accidents and post surgery

In one study with cancer patients the results showed that, “LRT significantly reduced fatigue in cancer patients as well as patients suffering from chronic fatiguing illnesses and other medical conditions. It also reduced the adverse effects of chemotherapy, resulting in improvements in incidence of fatigue, nausea, diarrhea, impaired taste, constipation, insomnia and other quality of life indicators.” (1)

Another study, proved, “…In cancer patients a placebo-controlled, cross-over clinical trial using Lipid Replacement Therapy plus antioxidants demonstrated that the adverse effects of chemotherapy can be reduced in 57-70% of patients. Dietary use of un-oxidized membrane lipids plus antioxidants is recommended for patients undergoing cancer therapy to improve quality of life.”(2)

In a number of studies on chronic fatigue the conclusions were, “In aging subjects mitochondrial function was restored to levels found in young adults in consort with reductions in fatigue, suggesting the anti-aging and anti-fatigue benefits…” and “The combination supplement was a safe and effective method to significantly reduce fatigue in long-term patients with intractable chronic fatigue.” (3 & 4)

Finally, “The results indicate that LRT plus antioxidants can significantly reduce moderate to severe chronic fatigue and restore mitochondrial function. Dietary use of un-oxidized membrane lipids plus antioxidants is recommended for patients with moderate to severe chronic fatigue.” (5)

The above demonstrates long-term health benefits of replenishing our cell membranes with therapeutic levels of glycophospholipids and the unique anti-oxidant formulation as provided in Lipid Replacement Therapy®.

1.” Lipid Replacement/Antioxidant Therapy as an Adjunct Supplement to Reduce the Adverse Effects of Cancer Therapy and Restore Mitochondrial Function”, Garth L Nicolson, Pathology Oncology Research, Vol 11, No 3, 2005. P. 139-44

2.” Lipid Replacement Therapy: a Functional Food Approach with New Formulations for Reducing Cellular Oxidative Damage, Cancer-Associated Fatigue and the Adverse Effects of Cancer Therapy”, Garth L. Nicoloson, Robert Settineri, Functional Foods in Health and Disease 2011 1(4):135-160

3. “Lipid Replacement as an Adjunct to Therapy for Chronic Fatigue, Anti-Aging and Restoration of Mitochondrial Function”, Garth L. Nicolson, JANA, Vol 6, No 3, 2003,

4. “Lipid Replacement Therapy with a Glycophospholipid Formulation with NADH and CoQ10 Significantly Reduces Fatigue in Intractable Chronic Fatiguing Illnesses and Chronic Lyme Disease Patients”, Garth L. Nicolson1, Robert Settineri, Rita Ellithorpe, International Journal of Clinical Medicine, 2012, 3, 163-170

5. “Lipid Replacement and Antioxidant Nutritional Therapy for Restoring Mitochondrial Function and Reducing Fatigue in Chronic Fatigue Syndrome and other Fatiguing Illnesses”, Garth L. Nicolson, Ph.D. and Rita Ellithorpe, M.D., Journal of Chronic Fatigue Syndrome 2006; 13(1): 57-68.