Essentials of Enzyme Nutrition Therapy: The Challenges of Our Modern World
By Mark Rojek 2003© All Rights Reserved*
Dr. Edward Howell, the pioneer in the clinical use of plant enzymes, began working at Dr. Henry Lindlahr‘s nature cure sanitarium in the 1920’s near Chicago, Illinois. Dr. Lindlahr is considered by many to be the “Father of Naturopathy” introducing the modality to the public after his own cure of diabetes by Father Sebastian Kneipp, a nature cure doctor in Bavaria. Father Kneipp used his “cold water cure” and herbs to restore the health of his patients.
Dr. Howell’s research and observations led him to believe that if he could replace the enzymes in cooked and processed food, the nutrients could be better utilized. In 1932 he founded National Enzyme Company to produce food enzymes to help in digestion. During his clinical practice, he witnessed hundreds of patients’ cures from chronic degenerative disease.
Dr. Howell advocated at least a 75% raw food diet together with taking digestive plant enzymes with the remainder of cooked food. In an interview conducted towards the end of his life, he remarked that even if someone ate a mostly raw food diet it still would be important to use concentrated plant enzymes. Replenishing what he referred to as the “enzyme bank”, was a sure way to maintain one’s health into old age and prevent disease.
While eating an entirely raw food diet would seem ideal, in most cases it would not be realistic for the majority of people at this time. Even the vegetables of the cruciferous family (broccoli, brussel sprouts, cabbage, cauliflower and kale) should not be eaten raw. They have thyroid inhibiting factors in them that should be destroyed by cooking. Though there is a growing awareness of diet, nutrition and alternative medicine, the average person leaves it to someone else to “fix” them. Thanks to the media’s flood of advertisements, they usually rely on over-the-counter drugs. The combination of propaganda and naïveté allows the average person not to take full responsibility for their own health.
Changing the system so that raw food was the main staple of society would demand a complete alteration of the food and medical industry and require re-education of food preparations. It might even challenge the belief systems in many cultures. It would confront the largest and most powerful industry in the world-the pharmaceutical / petroleum cartel. Monsanto would be the first to sue anyone having anything to do with it because it would invalidate their push for global market control of worthless genetically engineered seeds. Only organically cultivated seeds could be used because of the greater enzyme content inherent in plants once they were grown. All food would be organically grown, not only for preventing the pesticide/herbicide interference with normal bodily enzyme functions, but because mineral content is far more abundant; minerals being necessary co-enzymes. Appliance companies selling microwave ovens would be driven out of business, unless they developed new products. All those cooking shows on cable television would have to reinvent themselves by coming up with novel ways to prepare raw food.
There would be an ongoing debate, as there is now, whether to be vegetarians, since eating raw meat would probably be seen as abhorrently barbaric. Nonetheless, Dr. Howell specifically discussed how the Eskimo culture ate raw autolyzed meat. Howell points out the origin of the American Indian word Eskimo means “he who eats it raw”. The technique of autolysis involves keeping meat in the proper conditions of temperature and moisture for the enzyme cathepsin, found in meat tissue, to slowly break it down. It has been practiced for centuries. Traditionally, Eskimos survived brutal winters in the northern tundra living on raw pre-digested meats and blubber, without any fruit or vegetables or degenerative disease! When they began eating a “regular” diet of cooked foods high in carbohydrates, they experienced an increase in degenerative disease.
Howell explains that there is no evidence humans could live on an exclusively raw meat diet, but does make the point for autolysis. The hygienic conditions of those animals raised as food supply would have to be updated so they lived in extremely clean environments without cages and were free to roam. They in turn would not eat grains, but would be pasture fed. Antibiotics and other drugs would be used only in rare instances. This would cost several billion dollars or more to change world-wide. It is doubtful the food and pharmaceutical industry would go along with it. Since the bottom line in any industry is profits, there would be far less profit if farmers and the populace suddenly did not need the majority of pharmaceuticals.
Traditions and cultural implications aside, the socio-economic structures we find ourselves in today’s world make it difficult to achieve this on a grand scale. Nonetheless, there are small groups around the world who are practicing this way of eating. They mostly advocate vegetarianism. Whether being a vegetarian is the most appropriate approach to health is still debatable; it is not to be addressed here. Even vegetarians have major health issues, sometimes far worse than non-vegetarians. What the author is addressing is the clinical use of enzymes as therapeutic tools for preventing, reversing disease and maintaining optimal health.
The therapeutic use of enzymes reveals significant differences between enzymes resulting from animal sources and those of plant origin. Today, animal-based enzymes are primarily derived from the pancreas of freshly slaughtered pigs. They contain the highest enzyme concentrations from animal sources we know of to date. They have been used since the early 1900’s and have been very effective under certain conditions. Some enzymes are obtained from plants including bromelain from pineapple, papain from papaya and nanokinase from soy fermentation. Other plant-based enzymes are produced from different fungal/mold species by “growing” them. Various enzymes can be cultured from these fungal/molds in very high concentrations. Contrary to popular belief, these enzymes do not contain any of the substances they were grown from. Laboratories manufacturing plant enzymes have independent laboratory assays available to verify this.
Enzyme Activation Dependent Factors
Vitamins and minerals are considered essential nutrients and their symptoms of deficiencies are well documented, often occurring soon after depletion. Signs and symptoms of enzyme deficiencies take much longer to manifest and are very often missed in clinical evaluations. Enzymes are usually bound to either a mineral or vitamin, which are co-enzymes. Unlike most vitamins and minerals, enzymes are unique requiring four specific conditions for activation in order to function. These are:
|Ideal temperature range|
|The exact pH (alkalinity or acidity)|
|A specific substance (substrate) to work on|
Water: The Gift of Life
In order for enzymes to be active, moisture must be present. Enzymes will not work in a dry environment. They must have moisture. All legumes, nuts and seeds contain enzyme inhibitors. The inhibitors prevent those foods from spontaneously growing. The inhibitors also nullify the body’s own digestive enzymes from working on them. This is why they are so difficult to digest and why we feel tired after eating them. It costs the body great amounts of energy to digest them. Heating will destroy enzyme inhibitors but will also destroy the enzymes themselves. Soaking these foods for at least 12 hours not only destroys the inhibitors but activates the enzymes. Once activated, enzymes will begin breaking down proteins, fats and carbohydrates within the legume, nut or seed giving the body pre-digested food.
In his book, “Your Body’s Many Cries for Water”, Dr. Fereydon Batmanghelidj documents chronic dehydration as a causative factor for many health problems such as asthma, arthritis, allergies, back pain, hypertension, migraine headaches, and other degenerative diseases. Coffee, alcohol, manufactured beverages and many of the pharmaceutical drugs dehydrate the body. He believes dehydration to be the root cause of many degenerative diseases.
Enzymes are the only substances capable of doing work in the body but need adequate moisture in order to accomplish this. Is it possible, that dehydration for extended periods inhibits or slows normal enzyme functions which could lead to disease? It may be an academic point of argument. When the body is dehydrated, the blood becomes thick. This makes normal bodily functions difficult to continue. Aspirin thins the blood but not without side effects. Drinking more water will also thin the blood. Supplemental enzymes will thin the blood but it takes large amounts to accomplish this.
There are several ways to view any health crises and there may be more than one way to remedy them. Finding the safest, natural and medically sound way of supporting the body to achieve resolution of any health crisis can be challenging for the average person. Having the media thrust advertisements on the one hand, and at the same time spewing propaganda about the questionable safety issues of natural remedies, it is no wonder most people are confused and leery.
Some will say: “What about vitamins and mineral depletion of the soil and our food as causative factors in disease? What about our polluted environment – the pesticides, herbicides and industrial waste?” Frankly, it should not take a rocket scientist to conclude how health damaging our waste and chemical toxicity has become. Eating organically grown food, avoiding junk food, genetically modified and microwaved, irradiated food are essential. Yet, if you eat cooked food, the body will still suffer from enzyme deficiencies. When there is enough of nature’s “labor force” – namely metabolic enzymes and fluid circulating throughout the body – digestion, tissue repair, growth, immune function and detoxification will proceed normally.
Dr. Loomis includes a 24 hour urinalysis in his system of evaluation. “Volume” represents how much fluid intake there is and how well the body eliminates it. In relation to chlorides and specific gravity, volume reveals sodium chloride (salt) intake and kidney function respectfully. Does one ingest too much salt or not enough? Does the patient drink enough water or too much?
Many people drink too many liquids (not necessarily water) with the belief they are doing their bodies good flushing out toxins. While encouraging elimination of toxins is beneficial, excessive fluid intake can deplete and change the electrolyte balance resulting in numerous other health issues. Rather than guess how much water your body needs, following the recommendations in Dr. Batmanghelidj’s book is advised. In addition, utilizing Dr. Loomis’ 24 hour urinalysis will prove to the patient if they are drinking excessive, too little or just the right amounts of water daily. Adjusting water intake based on a 24 hour urinalysis is a clinically sound method of correcting electrolytes and balancing acid-alkaline conditions.
Temperature plays a crucial role in how active enzymes are within the environment they are working. Bromelain and papain are two protein digesting enzymes common in commercial and industrial use. Bromelain is utilized in the meat industry as a meat tenderizer because its ideal temperature range is between 120-160°F (48.89 – 71.11° C). Papain is used in the tanning industry to soften leather. Its optimal temperature is around 105°F (40.56° C). Bromelain and papain have had some success in clinical use as anti-inflammatory agents. However, their limited results might be due to the body’s temperature of 98.6°F (37.0° C) which is not ideal for them. Enzymes produced from mold/fungal organisms, however, have an ideal temperature range of 95-105°F (35.0 – 40.56° C). At the normal body temperature of 98.6°F, plant enzymes from mold/fungal origins are perfect. This will be seen later when we discuss fever in part three of this article.
Animal-based enzymes (pancreatin) are heat labile as well as plant enzymes. Dr. Howell noted heating food at 118°F (47.78° C) or greater, for any length of time destroys ALL the enzymes. Pancreatin, which has been used most extensively over the last 80 years, is subject to the same problems faced when manufacturing enzymes in the forms of tablets or capsules. Whether the enzymes are from animal or plant origins, when they are produced as a tablet the heat involved causes a loss of at least 50% of the enzyme activity in those products. Encapsulating enzymes is more advantageous because there is no heat involved in the processing and consequently, no loss of enzyme activity. There are also no binders, fillers or excipients as in tablets. These have the potential of causing some allergic reaction in some people.
Acidity and Alkalinity
One of the other major differences in using animal and plant enzymes is what is known as pH factor. In chemistry, pH is a measurement of the acidity or alkalinity of a substance. Vinegar is somewhat acidic while hydrochloric and sulfuric acids are highly acidic. Sulfuric acid is contained in car batteries. Hydrochloric acid is used commercially and is produced in the stomach. Lye, on the other hand, is extremely alkaline. It has been used to unclog plumbing drains in most commercial products. Interestingly, many of the newer plumbing and septic tank cleaners use concentrated plant enzymes.
Animal-based enzymes are limited as they can only work in a pH range of 7.2-9.0 which is alkaline Stomach acid concentrates down to about 2.0-3.0 during digestion. This is why animal-based enzymes can never digest food since they are limited to the alkaline end of the pH spectrum.
One of the most important functions of the body is to keep the blood pH between 7.35-7.45 which, as indicated above, is alkaline. The slightest deviation from this narrow range will throw the body into crisis. Since animal-based enzymes work only in an alkaline environment they have been shown to work best taken in-between-meals to breakdown unwanted protein such as undigested food remnants, virus, bacteria and other pathogenic microorganisms. They are also clinically proven in reducing inflammation.
Most of the original clinical studies using enzymes were done in Europe, particularly Germany. These were primarily performed using animal pancreatic enzymes. A library search of literature dating back to the early 1900’s shows most studies written in French, Italian and German. Very few studies were presented in English until the late 1930’s as found in the Index Medicus. Even today, the majority of clinical studies recorded in the medical literature still employs animal-based enzymes (pancreatin) and are from Europe.
Common usage for pancreatic enzymes is in the treatment of pancreatic insufficiency diseases such as steatorrhea (excessive amounts of undigested fat in stool), cystic fibrosis and pancreatitis. Results are mixed but generally, some help is obtained from pancreatin. While some of the inflammation is reduced to a degree, digestion is very little affected due to the fact pancreatin does not work in the acid pH of the stomach.
Plant enzymes, on the other hand, are known to have a much greater affect in these conditions due to the advantage of their broad pH range. A study out of England observed that a smaller amount of an acid-stable lipase from plant sources was as effectual as a twenty-five times larger dose of animal pancreatin.
One experience of the author involved a gentleman diagnosed with pancreatic cancer due in part to his alcoholism. His doctors prescribed pancreatin to aid with digestion and relieve inflammation. He was given 6 weeks to live. He had not found any relief with the pancreatin. Four weeks after the gentleman started a plant-based enzyme program, he lost touch with the author. The author succumbed to thinking he would never see this client again due to his death. One year later, he ventured into a restaurant and there was the former client with his wife and son enjoying a meal. The author asked in disbelief how he had survived. He explained he had continued taking plant enzymes, having purchased some from a health food store. He was still alive after several years, to the amazement of his doctors.
Plant-based enzymes work in a very broad pH range of about 2.0-12.0. This covers both the acid and alkaline ranges and makes them the most ideal for digesting food. Remember, Dr. Howell found in mammals a pre-digestion stomach, including humans. Based on the observations of Beazell et al, and others, Howell reasoned most digestion can take place in the stomach. Since plant enzymes survive extreme pH conditions this makes them perfect for digesting protein, starches and fats in the stomach. This digestion in the stomach also relieves the pancreas of its enzyme-producing burden. Plant enzymes are active in both acid and alkaline environments giving them greater access to digesting substances in blood, lymph and tissue that do not belong there.
Substrates: The Lock and Key
Lastly, enzymes need a specific substrate (substance) to work on. The analogy most commonly used is that of a lock and key system. Enzymes are very exacting in what they can work on. If the key does not fit the lock, nothing can occur. Protease works only on splitting protein down into smaller protein peptides and amino-acids. Lipase cleaves fats and oils into fatty acids. Cellulase breaks down cellulose, which is plant fiber. Pectinase works on pectin (fiber) from fruit. Sucrase breaks down sucrose; sugar obtained from beets or sugar cane.
One of the most commonly discussed enzyme deficiencies is lactose intolerance; the inability to digest the sugar component of milk. It has been observed through associates of Dr. Loomis that when someone is lactose intolerant, they are also usually intolerant of other sugars including maltose from grains and sucrose.
The enzymes necessary for digesting these sugars are produced by the villi of the small intestine. When someone over consumes sugar in its many forms over time, they exhaust their body’s ability to produce the specific enzymes necessary to digest those sugars. This is also the case with fructose when it is used as an additive derived from synthetic or even natural means, id enzymes are not present to digest it.
People who consume too much sugar also end up not being able to properly digest fats. This is especially true of women. The complex endocrine system of women warrants the ability to digest fats and protein to ensure necessary hormone production throughout life, especially during menopause. Hormones are primarily produced from fats, proteins and minerals. In fact, the major steroid hormones (aldosterone, cortisol, estradiol and testosterone) are derived from cholesterol.
Due to excessive sugar consumption during their lifetime and the inability to digest it, women experience difficult menopause because of mineral deficiencies brought about by the sugar. Difficult menopause also stems from long term problems of protein and fat digestion. The body uses food not only for energy but tissue repair (protein) and production of essential hormones.
The above example is true of any food that is consumed exclusively for long periods. Excessive consumption and the concurrent inability to digest those foods are known as dietary stress factors. Everyone is subject to dietary stress factors due to the repeated over consumption of particular foods. The base of the food pyramid advocated by the medical community is built upon carbohydrates. It has become clear to many that this is a faulty representation of the ideal diet. The rapid rise in diabetes, obesity and cardiovascular disease, especially in children, are the results of excessive carbohydrate and sugar intake and lack of exercise. The new kid on the block, “Insulin Resistance Syndrome” is just another example of the body’s inability to properly digest and utilize sugar and simple carbohydrates. It is believed by many to be the precursor of Type II Diabetes. It is further evidence of enzyme deficiencies, specifically the sugar and carbohydrate digesting enzymes.
Another group of enzymes, known as anti-oxidant enzymes, work on what are termed free radicals. Free radicals are the result of living in an industrial society. Externally they are caused by radiation, pollution, and toxins, while internally they are the result of normal metabolism. They are molecules without a paired electron in their outer ring. Electrons hold molecules together. Normally, a stable molecule has a pair of electrons. It will become unstable and reactive if there is an unpaired electron in the outer ring. Very often, free radicals are composed of an unstable oxygen molecule which will cause damage to the lipid portion of the cell membrane. It can also affect the protein and DNA of the cell. Antioxidants, including enzymes, can prevent or stop the damage caused by free radicals.
Glutathione peroxidase splits hydrogen peroxide into water and a single, stable oxygen atom. The main symptoms of excessive peroxide free radicals include heart and liver disease, premature aging, and skin disease such as age spots, cancer, dermatitis, eczema, psoriasis, and wrinkling. Glutathione peroxidase is dependent on the mineral selenium. If there is a deficiency of selenium in the soil or the food consumed, there may be a hindrance in the body’s ability to produce adequate amounts of glutathione peroxidase. Interestingly, epidemiological research in the United States and China shows areas with the lowest concentrations of soil selenium have the highest cancer rates, with the converse being true. This was first known in 1988 (3) and later confirmed in the latter 1990’s.
Superoxide dismutase (SOD) is an anti-oxidant enzyme responsible for cleaving the highly reactive superoxide radical, O2¯, into hydrogen peroxide and protecting cells from dangerous levels of superoxide. Working in tandem with SOD is the enzyme catalase. It breaks down the hydrogen peroxide that was created by SOD’s action on superoxide radicals. SOD/catalase deficiencies have been observed in inflammatory conditions, especially arthritis, bursitis and gout. In the field of anti-aging medicine, it is believed that supplemental anti-oxidant enzymes can slow the aging process. By curbing free radical processes, one may stop the damage done to cell membranes, strengthening the permeability of the cell making it less prone to invasion by pathogens or environmental pollutants.
Absorption of Exogenous Enzymes across the Gut
One of the arguments against using supplemental enzymes are that they are protein macromolecules and therefore are denatured or destroyed by action of hydrochloric acid produced inside the stomach. As such, they cannot cross the Brush border of the intestine intact. Even if they did cross over, they are nothing more than a trigger for the production of endogenous enzymes. As described below, these and other arguments have been proven incorrect.
A macromolecule is a compound of 1,000 or more atoms bound together. There is overwhelming evidence that macromolecules do in fact, cross the gut lumen intact. In 1904 Drs. Ganghofer and Langer demonstrated large protein molecules were absorbed across the intestinal gut without being degraded and were still capable of functioning. (4)
Morris documents intact absorption of gamma globulin in newborns. He recounts how infants’ first milk is colostrum which sets up the infants’ digestive immune function. (5) Both gamma globulin and colostrum are protein. Professor Seifert of the University of Kiel not only demonstrated the absorption of gamma globulin, he proved by means of immunological testing they were intact entering the rest of the body unaffected and in full molecular size. 6-8
Walker and others documented extensive work on intestinal uptake of macromolecules in relation to immunization. (9-11) Gardner specifically writes about the gastrointestinal assimilation of intact proteins. (12,13) Other animal and human studies describe numerous intact proteins including animal-based and plant-based enzymes being absorbed into the bloodstream following oral administration. (14-17)
In one study, cancer patients with known inflammatory conditions (deep and superficial thrombophlebitis of the extremities) were given doses of proteolytic enzymes either orally or intramuscularly of trypsin and chymotrypsin. Measurements of blood levels of both enzymes showed marked increases within 30 minutes with a decline to base levels at the end of 24 hours. These results occurred with both orally administered and intramuscularly injected enzymes. Since the orally administered enzymes did increase the blood esterase substantially it was concluded that, “…orally administered chymotrypsin and trypsin resulted in specific esterase activity changes in blood indicating absorption of the enzymes given, rather than release of other enzymes from the intestinal tract. …” (18) Unfortunately, this study was only interested in whether or not proteolytic enzymes could be absorbed across the gut wall. There was seemingly no interest in what the effects might be from the enzymes themselves on the inflammation or cancer.
In another study, lipase was found to be recycling from across the intestinal lumen into the lymph system and back to pancreatic acinar cells, where the cycle repeated itself. (19) This circulation of enzymes via the lymph and blood systems is similar to the recycling of bile salts by the liver.
Over the last century, doctors have sought to treat human ailments with a variety of natural and not-so-natural methods. Driven by the financial gains of pharmaceutical companies, research scientists have tried to unlock the secrets of nature to synthesize active ingredients of plants and animals. The amount of money spent on health care in the United States per person based on per capita far exceeds any other country. Yet, there is rampant illness with always the promise from pharmaceutical companies of yet another discovery just around the corner. Most people have come to expect the “Magic Bullet” pill that will do everything for them. Even in the natural health food industry, the latest vitamin/mineral supplements have everything except the kitchen sink thrown in for good measure.
In the early 1900’s radiation and surgery became the mainstays of treatments. By the 1940’s pharmaceutical drugs turned into the miracle cures. We’ve moved into an entirely new and uncharted territory, becoming cocky with the analysis of the genome and the ability to tamper with life. Cloning of animals and genetically modified drugs are the next promise for the future. Irradiated and genetically modified foods will feed the world, but at what cost?
All of the above factors will provide continuing evidence of enzyme deficiencies leading to more obscure and unrecognizable disease. Biological and chemical terrorism now threatens our existence, but so does the manipulation of our food.
Throughout history, the discoveries made by scientists usually have had a blind spot. That spot is the gaping hole of the future of this planet including everyone and everything on it. In the Hindu and Buddhist religions, Karma is the principle of cause and effect. It has been described in many ways, in many languages by prominent religious leaders and physicists as well. “What ye sow, so shall ye reap” if you are Christian. What we do now will forever affect the world we live on and in. In order to survive, food, water and air are essential. We can control what we eat, drink and breathe, so long as we are informed and educated.
The ongoing work of Dr. Loomis and his associates attest to the best kept secret in the field of nutrition. You are not necessarily what you eat, but what you can digest. Improved digestion through plant enzymes should be the starting point in any health program. When the body can get what it needs, when it needs it, it will perform wonders and even miracles. As Dr. Howell said, “Without enzymes, life itself would not be possible.”
References: The following are incomplete and out of order as they appear in the printed article. Corrections are forthcoming.
- Beazell, “A Reexamination of the Role of the Stomach in the Digestion of Carbohydrate and Protein”, Journal of Laboratory and Clinical Medicine 1941; Journal of Physiology 1941
- Ganghofer, D. and Langer, J., “Uber die Resorption gewisser EiweiBkorper im Magendarmkanal Neuborener Tiere und Sauglinge”, Med Wochenschr., 51:1497, 1904
- Morris, I.G., “Gamma globulin Absorption in the Newborn”, Handbook of Physiology, 75:1491-1512, (1978)
- Seifert, J. et al, “Quantitative analysis about the absorption of trypsin, chymotrypsin, amylase, papain, and pancreatin in the G.I. tract after oral administration.” General Physician (Allgemeinarzt) 19 (4): 132-137 (1990)
- Seifert, J.: Ganser, R.: Brendel, W.: “Absorption of proteolytic enzymes of plant origin from the G.I. tract into the blood and lymph of adult rats.” German Journal of Gastroenterology (Z. Gastroenterol.) 17: 1 (1969)
- Seifert, J.: Siebrecht, P. et al.: “Amylsae absorption and transport via blood and lymph after oral administration.“ Digest Biol. Sci. 41: 1593 (1986)
- Walker, W.A., Isselbacher, K.J., Bloch, K.J.: “Intestinal uptake of macromolecules: effect of oral immunization.” Science 177:608-610 (1972)
- Walker, W.A., Isselbacher, K.J., Bloch, K.J.: “Intestinal uptake of macromolecules. II. effect of parenteral immunization.” J of Immunol 111:221-226 (1973)
- Walker, W.A., Wu, M., Isselbacjer, K.J, et al “Intestinal uptake of macromolecules.III. Studies on the mechanism by which immunization interferes with antigen uptake.” J Immunol 115:854 (1975)
- Gardner, M.L.G., “Gastrointestinal absorption of intact proteins.” Ann Rev Nutr 8:329-350 (1988)
- Gardner, M.L.G., “Intestinal assimilation of intact peptides and proteins from the diet-A neglected field?” Biol Rev 59:289-331 (1984)
- Jacobson, I., et al: “Human beta-lactalbumin as a marker of macromolecule absorption.” Gut 27:1029-1034 (1986)
- André, C., et al: “Interference of oral immunization with the intestinal absorption of heterologous albumin.” Eur J Immunol 4:701-704 (1974)
- Dannaeus, A., et al: “Intestinal uptake of ovalbumin in malabsorption and food allergy in relation to serum IgG antibody and orally administrated sodium chromoglycate.” Clin Allergy 9:263-270 (1979)
- Pelot, D., Grossman, M.I., “Distribution and fate of pancreatic enzymes in the small intestine in the rat.” Am J Phisiol 202:285-288 (1962)
- Ambrus, J.L., Lassman, H.B., De Marchi, J.J.: “Absorption of exogenous and endogenous proteolytic enzymes.” Clin Pharm and Therap 8 (3): 322-328 (1967)
- Papp, M., Feher, S. Folly, G, Horvath, E.J.: “Absorption of pancreatic lipase from the duodenum into lymphatics.” Specialia 13(9) 1191-92 (1977)
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